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The signal strength was measured on a microplate reader at 450 nm and was quantitatively proportional to the amount of BDNF or proBDNF captured in the well

Figure 7D)

In summary, FOXO4-DRI exerts its anti-aging effects by inhibiting the binding of FOXO4 to P53, promoting P53 phosphorylation, and facilitating the translocation of p-P53 from the nucleus to the cytoplasm for its functional role

The authors reported the dual function of tumor-secreted mature DPP1 in neutrophil recruitment to metastatic niches and NETosis induction