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Treatment doses depend on the cause: pernicious anaemia typically requires intramuscular hydroxocobalamin 1,000 micrograms three times weekly initially, whilst dietary deficiency may be treated with oral cyanocobalamin 50150 micrograms or 1,000 micrograms daily

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Because the pancreas provides critical enzymes, as well as calcium required for vitamin B 12 absorption, pancreatic insufficiency may contribute to vitamin B 12 deficiency

Relapse was defined as the first occurrence of one or more of the following criteria: A pre-planned interim analysis demonstrated a statistically significantly longer time to relapse in patients randomized to the ABILIFY MAINTENA group compared to placebo-treated patients and the trial was subsequently terminated early because maintenance of efficacy was demonstrated

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