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Modern pharmacokinetics has underscored the importance of a loading dose to achieve circulating values above bacterial Minimal Inhibitory Concentrations (MIC) to reduce the risk of resistance 6,7

However, when ipilimumab is used as a single drug it only achieved ORR of 18.0%, as per the findings of a phase II randomized trial [284]

Those followed with diet, exercise, and no medication, gained a mean of 7%