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The C max of panduratin A after oral administration of 45 mg/kg pure panduratin A surpassed the IC 50 value, by approximately 15-fold, of that obtained in an in vitro study using SARS-CoV-2, while the minimum plasma concentration at 24 h remained approximately 10-fold higher than the IC 50 value
Although there is a dearth of bioavailability data for many of the peptide nasal sprays, a study showed that direct intratracheal instillation of a lyophilized powder at high concentrations could achieve reasonable levels of systemic absorption [13]
The clinical evidence base supports its use as a tool for maintaining antioxidant status, supporting liver and immune function, and reducing oxidative burden, particularly in individuals whose endogenous production is compromised by age, chronic stress, illness, or inadequate nutrient precursor availability
