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Studies have found that with ALD progression, at the phylum level, the abundance of Proteobacteria increases while that of Firmicutes and Bacteroidetes decreases

Beyond calcium signaling, BDNFTrkB-T1 interactions also regulate astrocytic function by modulating the activity of the GABA transporter GAT-1, thereby influencing GABA uptake dynamics [352]

Adiponectin also decreases hepatic de novo glucose production and reduces free fatty acid levels in the liver (196), thereby mitigating hepatic steatosis, enhancing insulin sensitivity, and improving the circulating lipid profile ( Figure 1 Section E)

iii) High risk: Three or more criteria rated as unclear or at least two criteria not met