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H&E staining Formalin-fixed and paraffin-embedded mouse skin specimens were cut into 4-m sections, stained with hematoxylin and eosin (H&E), and observed using light microscopy

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Blood Collection and Biochemical Analysis At the end of the treatment period (21 days), blood samples (7ml) was obtained from the retro-orbital sinus of each animal under mild ether anaesthesia into a heparinised EDTA tubes to prevent coagulation