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doi: 10.1097/00008480-199810060-00014

Remove the pen from the skin after the second click or when the indicator shows the dose is complete

Minimizes the look of fine lines

Reported or theoretical concerns may include: Injection-site reactions Transient headache Nausea or mild gastrointestinal discomfort Fatigue or energy fluctuations Unknown long-term effects Potential immune reactions or quality concerns with non-regulated products Theoretical concerns include potential over-suppression of inflammatory responses at high concentrations, so monitoring markers such as CRP and IL-6 during extended use may be recommended by a qualified clinician

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