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Description

In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (47)

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treatment often starts with an aggressive loading dose of 1000 mcg injections several times a week before tapering to monthly or bimonthly shots once levels stabilize

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Clinical Evidence and Safety Profile of Combination Use Multiple randomized controlled trials support the safety and efficacy of DPP-4/GLP-1 combination therapy

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Weiss FD, Calderon L, Wang YF, Georgieva R, Guo Y, Cvetesic N, et al

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