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Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system

Access this article Similar content being viewed by others Abbreviations FAD: Flavin adenine dinucleotide FDA: Food and Drug Administration FLU: Fluoxetine GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSSG: Oxidized glutathione, glutathione disulfide GST: Glutathione S -transferase IC 50 : Half-maximal inhibitory concentration K i : Inhibition constant, dissociation constant of the enzymeinhibitor complex K m : Michaelis constant K s : Dissociation constant of the enzymesubstrate complex NADP: Nicotinamide adenine dinucleotide phosphate, oxidized form NADPH: Nicotinamide adenine dinucleotide phosphate, reduced form NFLU: Norfluoxetine PLIP: Proteinligand interaction profiler ROS: Reactive oxygen species SOD: Superoxide dismutase SSRI: Selective serotonin reuptake inhibitor TAS: Total antioxidant status TPT: Transplacental transfer V m : Maximum velocity References Altschuler LL, Cohen L, Szuba MP, Burt VK, Gitlin M, Mintz J (1996) Pharmacologic management of psychiatric illness during pregnancy: dilemmas and guidelines

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