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This is based purely on studies done in rodents so we dont know how that extrapolates to humans, yet

It should also be noted that subjects in the alternative treatment arms (2 h30 min, 4 h30 min, 6 h30 min, and 2 hnight), with lower semaglutide exposure, were dosed in the evening with pre-dose fasting during the day, whereas subjects in the reference arm night30 min were dosed in the morning with pre-dose fasting overnight

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This is more of a concern for people with diabetes but should be monitored in any patient using semaglutide

Contact your healthcare provider immediately if you develop jaundice (yellowing of skin or eyes), dark urine, persistent right upper quadrant abdominal pain, unexplained severe fatigue, or persistent vomiting