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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)

Stimulation with synthetic GLP-1R agonist confirmed different food-motivated behaviors in female rats and their interaction with central estrogen signaling ( 26 )

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A qualified provider should weigh clinical evidence, individual patient factors, and availability when recommending either option