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212 Similarly, Cristina Gonzalez-Correa et al found that in a mouse model of systemic lupus erythematosus, TMAO may induce elevated NADPH oxidase activity and vascular endothelial oxidative stress by inhibiting Nrf2-mediated antioxidant defense mechanism

Your body communicates through symptoms, and while these signs dont conclusively prove toxin overload, theyre worth paying attention to if they persist without another clear explanation