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The injectable 500 mg/mL solution bypasses the gut, which sidesteps the absorption-driven GI complaints of oral dosing but injection carries its own generic considerations, the local injection-site reactions (pain, redness, irritation) common to any intramuscular or subcutaneous injection

Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e

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Notably, the enzyme has been linked to obesity and type 2 diabetes (T2D)