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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

Polakof, S

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Subsequently another work of the same research team analyzed the metabolic effects of CACT down-expression in human myocyte cells stably transfected with CACT antisense cDNA