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[ 3 ] Early experiments in animal models suggested that the administration of DSIP can increase slow-wave sleep in these models and potentially regulate sleep patterns

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However, overstimulation of melanocytes can cause excess melanin deposition, leading to skin pigmentation or hyperpigmentation

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Insulin resistance , a central feature of impaired glucose metabolism and metabolic syndrome, may partly explain the link, because it increases urine acidity and has been associated with uric acid stone formation (Ahmed 2014)