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Reduced inflammation throughout the body

Glucagon receptor activation directly drives: Thermogenesis (caloric burning through heat generation) Hepatic fat mobilization (clearing fat from the liver) Resting metabolic rate increase The glucagon component explains why retatrutide achieves greater fat loss than tirzepatide even after accounting for the GIP addition

However, GLP-1 also has other important actions such as promoting somatostatin release from pancreatic delta cells, which in turn counteracts or inhibits the secretion of glucagon from alpha cells of the pancreas

Figure 10 shows how the technique gained popularity over time

Potential complications include hematoma, nerve injury, infection, asymmetry, and prolonged swelling or bruising