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& Prina-Mello, A

PMCID: PMC2964977

Understanding the differences between Phase I and Phase II metabolism is crucial for assessing the overall metabolic fate of drugs and xenobiotics, predicting their pharmacological activities and toxicity, and optimizing drug therapy

Consequently, GPX4 inhibitors behave as a alternative class of senolytic drugs that kill senescent cells by ferroptosis and can be used to treat senescence-associated diseases such as cancer

SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis