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Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk

7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008) , Couran Cove, Australia, 7-11 December 2008

When GSSG accumulates excessively due to dysfunctional SLC33A1 activity, this inhibits enzymes required for proper disulfide bond formation and quality control, resulting in protein misfolding and aggregation within the ER