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Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial

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Subcutaneous tissue provides a relatively avascular depot from which the large peptide molecule (molecular weight approximately 4,813 Da) is gradually absorbed into systemic circulation, achieving peak plasma concentrations approximately 8 to 72 hours post-injection, according to the FDA prescribing information

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