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Orlistat is indicated for patients with a BMI 30 kg/m 2 or 28 kg/m 2 in association with other risk factors (e.g., hypertension, diabetes, hyperlipidaemia) [10]

2.Glutathion synthesis The first step of GSH synthesis is rate-limiting and catalyzed by glutamate-cysteine ligase (GCL) formerly referred to as -glutamylcysteine synthetase (GCS)