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At the same time, compared to HCs, the levels of a wide range of metabolites such as glutamine, asparagine, N-Formimino-glutamate, putrescine, serotonin, kynurenine, 2-Aminomuconate, Cys-Gly, 5-Aminolevulinate, and pyridoxine were reduced in the plasma of R group ( Figure 5C , Supplementary Figure 4A )

This combination is more recovery-focused than hormone-focused

Studies utilizing GPX4 degradation to induce ferroptosis revealed that lipid peroxidation propagates ferroptotic signaling through intercellular transfer via plasma membrane contact, amplifying necrotic tissue expansion 31

This reduction in taste reward may contribute to the weight loss effects