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10.1016/j.phymed.2022.154589 36 KahkeshaniN.FarzaeiF.FotouhiM.AlaviS

Incretins modulate pancreatic islet secretions as part of the "entero-insular axis," and their primary function is to regulate postprandial nutrient utilization and storage

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The European Medicines Agencys 2025 synthetic peptide quality guideline treats peptide-related impurities as first-class critical quality attributes: deletion and truncated sequences, dimers, oligomers, and degradation products each need characterization, with European Pharmacopoeia practice pointing to reporting thresholds at 0.1% and identification thresholds above 0.5% for peptide-related impurities in pharmaceutical use

Swollen lymph nodes occurring during GLP-1 therapy typically have alternative causes requiring appropriate clinical evaluation