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It is not clear if these proteins themselves play a physiological role in IC/BPS, or if the general increase in these specific peptides is a consequence of other processes, such as increased protease degradation

It can also reduce inflammation

doi: 10.2337/dc22-1127 20

To investigate the effects of miR-221 on the biological function of hair follicle keratinocytes (HF-KCs), we performed western blot assays and found that overexpression of miR-221 significantly reduced IGF-1 expression, leading to a subsequent decline in the proliferation ability of HF-KCs

No obvious toxicity has been reported in rodent studies at effective doses