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The intron-tagged mScarlet-Metallothionein 1E ( mScarlet-MT1E ) 1321N1 cell line was generated as described previously (Reicher et al, 2020)
Results: The models explain why women of childbearing age have higher glutathione than men, and that this is caused by the balance of activation of glutamyl cysteine synthetase (GCL) and glutathione peroxidase (GPX) by estradiol
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Further controlled human studies are necessary to clarify safety parameters, long term outcomes, and any potential translational relevance within clinical research frameworks
As a key antioxidant system enzyme, GPX4 can catalyse the reduction in lipid peroxides in complex cellular membrane environments [27]
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