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Additionally, SIN influences the nuclear factor erythroid 2-related factor 2 (Nrf2)/ heme oxygenase-1 (HO-1) pathway, leading to the suppression of NF-B activity in mouse chondrocytes, thereby curbing inflammatory reactions and the breakdown of extracellular matrix elements

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J Orthop Res 24:11091117 Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, Perovic D, Aralica G, Zarkovic N, Borovic S, Srdjak M (2003) Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth