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Injectable GLP-1 drugs require refrigeration as stated in their package inserts, and the FDA recommends not using any that arrive warm or with insufficient refrigeration

Unlike injectable formulations where absorption is reliable regardless of food intake or timing, oral tablets must be taken under precise conditions to achieve adequate bioavailability

Glucagon-like peptide-1 receptors in vagal afferent neurons are required for normal satiation, gastric emptying, and glucose homeostasis

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