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23 Vitamin C is water-soluble and is present in fruits and vegetables

Each has distinct clinical features but shares overlapping molecular mechanisms driven by chronic hyperglycemia-induced ROS overproduction

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For most patients with vitamin B12 deficiency, high-dose oral supplements are as effective as intramuscular injections at raising serum B12 levels and resolving symptoms

Although N-acetylcysteine (NAC) directly influences the pool of extracellular cystine and intracellular cysteine via a series of plasmatic redox reactions, in order to be effective, intracellular cysteine precursors must be designed to enter erythrocytes rapidly and use high activity enzymes within erythrocytes to liberate cysteine (Whillier et al., 2009