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Although inflammation is reflected in selective biomarkers, traditional inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate have also shown an increased trend in ME/CFS, particularly in those with mild/moderate disease generally not raised in ME/CFS (226)

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In fact, a plethora of studies clearly indicate that neuroinflammation is important to the progressive brain dysfunction seen in demented persons, who exhibit an array of cognitive deficits including non-spatial memory impairment 72,73