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Notably, the GLP-1R-GIPR co-agonist HISHS-2001 has slightly higher GLP-1R and GIPR potencies and lower beta-arrestin-2 recruitment to the GLP-1R than tirzepatide

Most patients begin noticing improvement in shedding and thickness within 36 months of consistent use

Demand for GLP-1RAs has increased significantly in recent years [See Figure 1], driven primarily by their use for weight-loss purposes rather than for diabetes