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Cell 42 , 160171 (2011)

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When gut bacteria ferment prebiotic fibers like inulin, they produce short-chain fatty acids including acetate, propionate, and butyrate

They are complementary: the gastric-emptying delay flattens the initial glucose rise, glucagon suppression trims the hepatic contribution, and reduced intake lowers the total nutrient load

While the appetite suppressive effects of amylin and GLP-1 receptor agonists are known to involve direct actions in the brain 6,7,9,10,12,13,14 , uncovering the neuroanatomical site(s) of action and the physiological mechanisms that mediate the anorectic response remains an area of intense research focus