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The first step is catalyzed by-glutamylcysteine synthetase (GCL) and is considered to be rate limiting step

Testosterone is ~98% bound to serum proteins (sex hormone-binding globulin (SHBG) and albumin) and only 12% of testosterone is unbound or free

1 2 "In Silico-Based Experiments on Mechanistic Interactions between Several Intestinal Permeation Enhancers with a Lipid Bilayer Model"

[12] [13] Diagnosis involves excluding other conditions that might explain the symptoms, with basic investigations such as full blood count, inflammatory markers (ESR/CRP), thyroid function, and vitamin D levels often considered

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