The trade-off is that slower escalation means slower weight loss initially, but the improved tolerability often leads to better long-term adherence and outcomes
The most frequent side effects of semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation
Given that weight loss may restore fertility in some individuals with obesity-related reproductive dysfunction, unplanned pregnancy becomes a possibility
The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview
So when you add that effect together with semaglutide that suppresses appetite, you get the synergistic effect where you get primarily loss in body fat and very little, if any, loss in lean mass