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Cost-Effectiveness of Improved Diagnostic Approaches Economic models comparing different diagnostic strategies consistently favor approaches that reduce time to diagnosis, even when these strategies have higher initial costs

Beyond simple actin sequestration, Bock-Marquette and colleagues reported in Nature (2004) that T4 activates integrin-linked kinase and Akt, promoting cardiomyocyte and epicardial cell migration and survival in mouse cardiac injury models, which established a signalling role separate from cytoskeletal buffering

Invoked mechanisms include modulation of osteoblastic and osteoclastic activity as well as stimulation of mesenchymal stem cell differentiation toward the chondrogenic lineage

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The molecular signaling that controls these phases involves intricate cascades of growth factors, transcription factors, and structural proteins