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By 6-12 months of consistent therapy, glutathione levels typically stabilize at elevated baselines that reflect the supplementation protocol while accommodating individual metabolic factors affecting glutathione turnover

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investigated the pharmacological modulation of mitochondrial function in intestinal diseases, including CRC, offering insight into mitochondrial dynamics and bioenergetics [25]

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The most relevant systematic review found 36 studies, but 35 were preclinical and only 1 was clinical, with no large human efficacy trials identified [4]