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Description

Some aspects of this, in relation to cell proliferation can already be ascertained in standard in vivo toxicity testing for pesticides and pharmaceuticals (e.g., in OECD TG 407/408) (258)

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The presence of resistance-associated substitutions (RAS) as natural polymorphisms in the NS5B gene affects HCV susceptibility to sofosbuvir and dasabuvir and may limit the clinical effectiveness of DAA combinations containing these drugs 45,46

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