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Very high baseline A1C and long-standing diabetes Pre-existing diabetic retinopathy or macular edema Concurrent insulin therapy Large and rapid A1C reductions over a short period Additional vascular risks such as high blood pressure, high cholesterol, kidney disease, or sleep apnea Improving glucose control remains important for long-term eye health

GLP-1 medications slow gastric emptying, meaning food remains in the digestive system longer

The same study also proved its safety for obese and overweight adults without diabetes, deeming it acceptable from both a patient and clinical perspective

However, healthcare providers do not typically recommend this approach