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Approval would help the company in its head-to-head market battle with main rival Novo Nordisk in the GLP-1 category, whose semaglutide is already approved for cardiovascular risk reduction in adults with type 2 diabetes and overweight/obesity with established heart disease, and also showed a benefit in heart failure in the STEP-HFpEF trial

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External Factors Affecting Accuracy Hydration levels: Dehydration can make it harder to obtain a proper blood sample, potentially skewing results

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[1] [8] In the SURPASS clinical trial program, tirzepatide demonstrated hemoglobin A1c reductions of up to 2.5% from baseline and superior glycemic control compared to semaglutide 1 mg in the SURPASS-2 trial