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Repeated freeze-thaw cycling is a known nucleation trigger for amyloidogenic peptides as well as a general cause of peptide loss

In cellular models of KAT6A syndrome, this specific combination successfully rescued cell bioenergetics, increased cellular NAD+/NADH ratios, and physically repaired the cells' histone acetylation levels

That ratio concerns researchers and clinicians alike

The pigmented cells are negative on the Prussian blue stain