86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression
Rather than being rapidly digested, resistant starch reaches the large intestine where, just like fibre, it feeds beneficial gut bacteria
The biology behind it is not fully settled, but dose-response curves that peak and then fall off are common for signaling molecules, where too much of a stimulus can desensitize or overshoot the system it is meant to nudge
Nevertheless, despite its popularity, this combination is not based on any independent scientific study
No, kojic acid is not banned in Japan