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Cannabis may also impair the judgment needed to recognize hypoglycemia symptoms, particularly in patients on concurrent diabetes medications

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Haden ST, Glowacki J et al

Some people experience digestive upset from high-dose B12 supplements

Warning signs include persistent fatigue despite adequate sleep, cold intolerance (especially cold hands and feet), menstrual irregularity or cessation in female subjects, hair thinning or shedding, and mood disturbances (irritability, low motivation)