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(8) Furthermore, FOXO4's role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways

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REDEFINE-1 (NEJM 2024, n=3417, 68 weeks): CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) 22.7% weight loss (ozempic 2.4 mg 16.1%)

Figure 7 Dihexa does not protect hair cells from cisplatin Previous work with chemical and genetic cell death modulators suggests that cisplatin and aminoglycosides share some cell death pathways while also activating a distinct subset of signaling pathways (Owens et al., 8)