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Valentino MA, Lin JE, Waldman SA

Specifically, microglia-derived IL-1, TNF, and complement component 1q activate astrocytes via the NF-B signaling pathway, resulting in reactive astrogliosis characterized by impaired neuronal support, reduced synaptic functions, and increased neuronal vulnerability [93]

Failure on any of these can trigger disciplinary action even if federal laws arent directly violated