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During the pathogenesis of OA, JUN directly binds to the promoter of NCOA4 and initializes its transcription, increasing ferritinophagy degradation, leading to ferroptosis and extracellular matrix degradation in chondrocytes

Early research suggests that L-carnitine given intravenously (by IV) daily for 7 days increases weight loss and reduces waist circumference in people with metabolic syndrome

This observation is consistent with a previous report demonstrating that long-term HFD consumption impaired liver regeneration in C57BL/6 mice through suppression of NF-B activation 44

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However, a significant challenge in this area of research involves the failure to define the contribution of ferroptosis to neurological impairment after hemorrhagic stroke and the difficulty of determining which specific period after hemorrhagic stroke plays a vital role in the ferroptosis effect