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It is not approved for human or veterinary use, diagnostic procedures, or therapeutic purposes

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One mechanism detail worth knowing: repeated high doses can blunt the response over time (desensitization), which is part of why dosing near the saturation point, not above it, is the common approach

If you find that your facial flushing lasts for a while, remains for longer than usual, or appears more and more frequently, its time to go to the doctor

The bioavailability of 25(OH)VD 3 in the blood in response to dietary VD intake varies significantly among individual subjects and is dependent on the status of the VD metabolism genes 14,15,16,17