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A conservative escalation for autoimmune patients might look like this: 2.5 mg weekly for six to eight weeks (instead of four), followed by 5 mg weekly for eight to twelve weeks with careful monitoring of both metabolic and autoimmune markers, then cautious escalation to 7.5 mg only if tolerated and if additional metabolic benefit is desired

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2 Matthew Stefan, Matthew Sharp, Raad Gheith, Ryan Lowery, Charlie Ottinger, Jacob Wilson, Shane Durkee, and Aouatef Bellamine

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Additionally, we have developed novel DDX3X PROTAC degraders and compared their anti-tumor efficiency with RK-33, showcasing their great potential and advantages in targeting DDX3X for lung cancer therapeutics