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J Biol Chem (2014) 289:1988193

Digestive side effects are a major reason titration is gradual

The main difference is that they are approved by the US Food and Drug Administration (FDA) to treat different health conditions: weight loss and sleep apnea in the case of Zepbound and type 2 diabetes in the case of Mounjaro

Managing withdrawal symptoms after discontinuation is another area where Ozempic has more documented guidance, while retatrutide data on this topic does not yet exist