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Liddell, [email protected] This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Clinical validation Even though several earlier studies on different stimuli-responsive hybrid nanomaterials demonstrated encouraging outcomes in both in vitro and in vivo investigations of wound healing and tissue regeneration, issues still need to be resolved before applying them in clinical settings

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