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10.7554/eLife.34408 16 HendersonC

rather, it is the cascade of events associated with inflammation that contribute to unwelcome sensations

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Iron dyshomeostasis in glial cellseven in the absence of cell deathcontributes to the vicious cycle: iron-loaded microglia directly secrete IL-1 and IL-18 to fuel neuroinflammation (Ryan et al., 2023), while reactive astrocytes release hepcidin and pro-inflammatory cytokines, which elevate neuronal iron load and sensitize neurons to ferroptosis (Xiong et al., 2016

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