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It is noteworthy that the discovery of these drugs for weight loss was serendipitous: they were being developed for improving glucose regulation and unexpectedly were found to achieve significant weight reduction
They were reported as emerging potential biomarkers and a therapeutic target for several diseases, including AITD [41]
The alendronate group demonstrated significant improvement in morphological features of bony samples with obvious records of apparent intact trabecular bone with up to a 2.4-fold increase of relative trabecular bony area
The FOXO signaling pathway also contributes to ROS reduction by enhancing the expression of antioxidant enzymes, promoting ROS clearance, and regulating cellular redox balance
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