Neurobiology : Examined for neuroprotective properties and circadian rhythm regulation
Pilocarpine-induced seizure triggers glial activation and promotes the production of various inflammatory mediators, thus initiating a cascade of inflammatory processes in the hippocampus (Shapiro et al., 2008
In vitro studies confirm minimal cytotoxicity with no impact on cell viability up to 100 M concentrations across multiple cell types, though higher concentrations may produce non-specific effects that could confound experimental results
The spectrum of NAFLD ranges from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma [3]
An RCT in 72 patients with NAFLD found that NAC (600 mg twice daily) for 3 months significantly improved liver enzymes (ALT, AST) and markers of oxidative stress compared to control, though it did not significantly improve liver histology on biopsy (Khoshbaten et al., Hepat Mon, 2010) [33]
